Oncology & Metabolism Seminar Series Hosted by the Weston Park Cancer Centre

Date: Friday 25 October 2019
Time: 2.00 pm
Venue: Weston Park Lecture Theatre

Title: “The extracellular matrix as a nutrient source for breast cancer cells”

Internal seminar by: Dr Elena Rainero
Lecturer, Department of Biomedical Science
University of Sheffield

2016- present: Lecturer, The University of Sheffield (UK) 2015–2016: Research Fellow, The University of Sheffield (UK) 2009–2015: Post-doctoral researcher, the Beatson Institute for Cancer Research, Glasgow (UK)

The research in my lab focuses on understanding the role of extracellular matrix (ECM) internalisation in cancer. The ECM is a complex network of secreted proteins, such as collagens, laminins and fibronectin, which, besides providing support for tissues and organs, also plays an active role in controlling a variety of cellular processes, including cell migration, proliferation and oncogenic transformation. Our recent data indicate that the internalisation of ECM components is strongly upregulated in invasive cancer cells, compared to normal epithelial cells and non-invasive cancer cells, suggesting that ECM uptake might be involved in controlling invasive cell migration. Furthermore, we also found that ECM endocytosis is able to sustain cancer cell growth in nutrient-deprived conditions, raising the intriguing hypothesis that the ECM could represent a source of nutrients for starved cancer cells.

Registration is not necessary.