REMINDER: Department of Infection, Immunity & Cardiovascular Disease Seminar – Thursday 18th July 2019

Dr Helder Nakaya

Title:  “Recent Advances in Network Medicine”
Speaker:  Dr Helder Nakaya, University of Sao Paulo, Brazil.
Venue: Lecture Threatre 3, F Floor Medical School.
Time:  12:30pm – 1:30pm
Abstract:  Diseases are mostly a consequence of an abnormality in multiple genes. Network Medicine investigates how genes interact to each other in complex intracellular and intercellular networks. The talk will show the recent advances on this emerging field of research and its impact on precision medicine and drug repositioning.

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Date: Wednesday 31st July 2019
Title:  “Therapeutic vasculoprotection, autoimmune disease and premature atherosclerosis”
Speaker:  Professor Justin Mason, Imperial College London.
Venue: Lecture Threatre 3, F Floor Medical School.
Time: 12:30pm – 1:30pm
Abstract:  The vascular endothelium is a critical interface, separating the organs from the blood and its contents. Endothelial cells exhibit a wide variety of functions and maintenance of endothelial homeostasis is a multi-dimensional active process critical for health. Disruption of homeostasis is a common feature of autoimmune diseases. The presentation will outline the relationship between systemic inflammatory diseases and premature atherosclerosis and cardiovascular events. Development of therapeutic strategies, which combine immunosuppression with vascular conditioning and reversal of endothelial dysfunction, remains an important goal for clinicians. The innate constitutive and response mode signalling pathways that drive vasculoprotection will be described and recent experimental work aimed at the therapeutic manipulation of these pathways to restore homeostasis will be shown.