REMINDER: Department of Infection, Immunity & Cardiovascular Disease Seminar – Tuesday 7th May 2019

Dr.Tom Clarke

Title: “Protection against respiratory infection by the microbiota”
Speaker: Dr Tom Clarke, Imperial College London.
Venue:  Lecture Theatre 3, F Floor Medical School.
Time:  12:30pm – 1:30pm
Abstract: Environmentally exposed surfaces in humans are colonized by a vast number of foreign microbes (the commensal microbiota) and these organisms play a key role in regulating mucosal and systemic immune function. Disruption of this relationship is linked to a wide variety of diseases and immune dysfunctions, including chronic inflammatory conditions at the mucosa, autoimmunity and increased susceptibility to infection by bacteria, viruses and parasites. There remains, however, a major gap in understanding the mechanistic basis for the influence of the commensal microbiota on immune function, especially systemic immunity. The broad theme of my research, therefore, is to understand how programming of innate immunity by the microbiota influences host responses to bacterial infection and vaccination, and how changes to the composition of the microbiota disrupts these responses.

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Date: Wednesday 26th June 2019
Title: “Regulation of lung pathophysiology via circadian control of Integrinβ1 and RhoA”
Speaker: Dr. John Blaikley, University of Manchester.
Venue:  Lecture Threatre 3, F Floor Medical School.
Time: 12:30pm – 1:30pm
Abstract:  In 2017 the Nobel Prize was awarded to researchers who discovered the circadian clock. It is now recognised that this clock alters 40% of known biological pathways; however the relevance of this clock and circadian biology to human pathophysiology is poorly understood. John Blaikley is a MRC clinician scientist investigating how the “clock” regulates pathophysiology in the lung. He has recently published papers showing that acute lung injury, asthma and wound healing are all under circadian control. Currently he is investigating the role of circadian biology in pulmonary fibrosis and pneumonia. During this talk he will discuss the translational relevance of pulmonary circadian biology and how its investigation can lead to novel therapeutic interventions.