REMINDER: Department of Infection, Immunity & Cardiovascular Disease Seminar – Monday 15th April 2019

Dr Greg Moseley

Title: “Viral hijacking of the Host DNA damage and Innate Immune Responses: Novel Disease Mechanisms and Therapeutic Targets”
Speaker: Dr Greg Moseley, Biomedicine Discovery Institute, Monash University, Australia.
Venue: Lecture Theatre 3, F Floor Medical School.
Time: 12:30pm – 1:30pm
Abstract: Despite a limited coding capacity, RNA viruses such as rabies (RABV) and Nipah (NiV) virus can arrest potent control over host cell biology, and are often highly lethal. Central to this are multifunctional viral proteins that can modulate critical cellular processes, in addition to mediating conserved roles in replication.

My laboratory seeks to delineate these functions to understand how viruses subvert cell biology, and thereby identify new targets to develop vaccines and antivirals.

I will discuss our recent progress on Henipaviruses and lyssaviruses, including new findings on viral targeting of the nucleolus and unexpected roles in modulating the DNA-damage response to control the host cell1. I will also discuss new data on viral antagonism of immunity2, and how this is informing potential methods to block viral immune evasion for vaccine/therapeutic approaches, as well as revealing fundamental mechanisms whereby viral proteins can ‘multi-task’ in coupling immune evasion and genome replication.

  1. Nat Commun. 2018; 9(1):3057; J Virol. 2015; 89(3):1939
  2. Biomol NMR Assign. 2018. doi: 10.1007/s12104-018-9841-4; Sci Rep. 2016; 6:33493; J Infect Dis. 2014;209(11):1744.

For enquiries, please contact: iicd@sheffield.ac.uk


FUTURE DATES FOR THE DIARY:

Date: Tuesday 7th May 2019
Title: “Protection against respiratory infection by the microbiota”
Speaker: Dr Tom Clarke, Imperial College London.
Venue:  Lecture Theatre 3, F Floor Medical School.
Time:  12:30pm – 1:30pm
Abstract: Environmentally exposed surfaces in humans are colonized by a vast number of foreign microbes (the commensal microbiota) and these organisms play a key role in regulating mucosal and systemic immune function. Disruption of this relationship is linked to a wide variety of diseases and immune dysfunctions, including chronic inflammatory conditions at the mucosa, autoimmunity and increased susceptibility to infection by bacteria, viruses and parasites. There remains, however, a major gap in understanding the mechanistic basis for the influence of the commensal microbiota on immune function, especially systemic immunity. The broad theme of my research, therefore, is to understand how programming of innate immunity by the microbiota influences host responses to bacterial infection and vaccination, and how changes to the composition of the microbiota disrupts these responses.