Title: ” The therapeutic potential of enhancing astrocytic Nrf2-signalling in combating neurodegeneration caused by cerebral hypoperfusion”
Venue: Rooms B02/B03, SITraN, 385a Glossop Road,
Sheffield S10 2HQ
Speaker: Dr Jill Fowler, Alzheimer’s Research UK Senior Research Fellow, The University of Edinburgh
Brain injury, including that due to stroke and head injury, is associated with an increased risk of cognitive deficits and dementia. The goal of my research is to understand the mechanisms by which stroke and head injury cause degenerative changes in the brain which can lead to dementia.
In 2006, I was awarded a research fellowship by the Alzheimer’s Society to examine the mechanisms by which head indury can lead to Alzheimer’s Disease. I established a model of mild traumatic train injury in mince which causes cognitive deviccits and axonal pathology. Wee are currently investigating novel proteins and pathways that are altered in response to mild head injury using a proteomic approach.
In 2015, I was awarded a senior research fellowship by Alzheimer’s Research UK to understand how stroke can lead to dementia. We are interested in a protective signalling pathway called Nrf2, which becomes activated when the cell encounters oxidative stress, and can switch on over 200 anti-inflammatory and anti-oxidant genes. We are investigating how stroke alters Nrf2 signalling, and determining if manipulating Nrf2 signalling with transgenic or pharamacological approaches can reduce neurodegeneration.
The ultimate goal of our research is to understand the pathological mechanisms that can lead to cognitive decline in dementia, with the aim of developing novel therapeutic approaches.