Title: “Is there a role for stem cells in regenerative neurology ?”
Venue: Rooms B02/B03, SITraN, 385a Glossop Road,
Sheffield S10 2HQ
Speaker: Prof Siddharthan Chandran, MacDonald Chair of Neurology, University of Edinburgh
Professor Siddharthan Chandran works in the emerging discipline of Regenerative Neurology. His research combines laboratory activity that includes human stem cells with specialist clinics (multiple sclerosis [MS] and motor neurone disease [MND]) to both study disease as well as undertake early-phase clinical trials.
The ultimate aim is to develop novel regenerative therapies for neurodegenerative disease.
Based at the Anne Rowling Regenerative Neurology Clinic, clinical research is founded on specialist clinics and linked disease registries to develop a clinical experimental infrastructure for longitudinal studies. Current collaborative clinical projects include:
- Scotland-wide platform for care, research, audit and trials in motor neurone disease (CARE-MND)
- Scotland-wide MS brain imaging and genomics clinical research study, towards precision medicine (FutureMS)
- Speak:Unique, the voicebank research project – using informatics to provide personalised synthetic voices for use in communication aids
- MS-SMART (phase 2) and MS-STAT3 (phase 3): major clinical trials in secondary progressive MS, led by UCL
Research in the lab is focused on the glial-neuronal interaction in health and disease. Current approaches include:
- In vitro modelling of TDP43 proteinopathies using patient-derived iPS cells that have been converted into a range of functional neuronal and glial subtypes
- In vivo modelling of the interactions between inflammation, neurodegeneration and repair in a mouse model of MS (Biozzi-EAE)