Title – NUDT22 is a P53-induced regulator of a novel pyrimidine salvage pathway
Speaker – Dr Patrick Herr, Research Fellow, Department of Oncology & Metabolism
Sheffield Cancer Centre Seminar Series
Date: Friday, 2 November 2018
Time: 14:00 – 15:00
Venue: Weston Park Hospital Lecture Theatre
Registration is not necessary.
The well described link between aberrant Wnt signalling and cancer raised my interested in translational cancer research. I therefore started my postdoc with Professor Thomas Helleday at the Karolinska Institutet in Stockholm, Sweden in 2012. My initial work on the link between transcription and homologous recombination-mediated DNA repair ultimately lead me to study the cell cycle, DNA replication and nucleotide metabolism.
My recent work is centred around the characterization of the previously unstudied NUDIX protein NUDT22. In a combined effort with members of the Helleday lab and external collaborators we identified a substrate and defined the crystal structure of NUDT22. Current efforts concentrate on deciphering the cellular function of NUDT22 and the development of small molecule inhibitors to target its enzymatic activity.