Success for Sheffield PhD Student at the Atlanta Vascular Mechanobiology Meeting 2018

Congratulations to Blanca Tardajos Ayllon (2nd year PhD student in the Department of Infection, Immunity & Cardiovascular Disease) on her recent success at the Atlanta Vascular Mechanobiology meeting.

Blanca (centre) receiving her award from Professor Hanjoong Jo (left)

Blanca was awarded the Best Abstract Award for her investigations of the influence of the NF-κB transcription factor subunit c-Rel in endothelial mechanobiology and atherosclerosis. It has been established that atherosclerosis develops at arterial regions exposed to disturbed blood flow, and also, that blood flow patterns regulate NF-κB-mediated transcription. Although some members of the canonical NF-κB pathway are known to respond to flow, the influence of blood flow patterns on c-Rel and its role in atherosclerosis are still unknown.

Blanca’s research has shown for the first time that disturbed blood flow at regions prone to atherosclerosis induces c-Rel, promoting endothelial proliferation. Her research suggests that c-Rel might contribute to the development of atherosclerosis, which could lead to the identification of c-Rel as new target for the prevention and treatment of this disease.

Blanca said “It was a very interesting and stimulating conference. I really enjoyed the opportunity to present my data and I got very useful feedback on my work. It was an unexpected surprise and honour to get one of the poster prizes and I am very pleased with the overall conference experience. I am looking forward to the 2019-edition in London!”