Title: “Mechanistic insights into the role of AP-4 and AP-5 adaptor protein complexes in neurodegeneration”
Speakers: Jennifer Hirst and Alexandra Davies, Cambridge Institute for Medical Research, University of Cambridge
Venue: Rooms B02/B03, SITraN, 385a Glossop Road, Sheffield, S10 2HQ
Jennifer Hirst is a Principal Research Associate in Professor Margaret Robinson’s lab at the Cambridge Institute for Medical Research. She is a cell biologist with interests in the machinery that is involved in transporting proteins between the various subcellular compartments. Her talk will focus on new mechanistic insights into the function of AP-5 (SPG48) and its associated proteins spastizin (SPG15) and spatacsin (SPG11), and how their loss could lead to the rare neurodegenerative disease hereditary spastic paraplegia.
Alexandra Davies is a final year PhD student in Professor Margaret
Robinson’s lab at the Cambridge Institute for Medical Research. The
focus of his PhD research has been the function of the AP-4 complex, and
in particular the cellular consequences of losing AP-4 and how this may
lead to the severe neuropathology associated with AP-4 deficiency. His
talk will focus on his use of advanced spatial proteomic techniques to
identify cargo proteins which are missorted in cells deficient in AP-4
and their model of how this could lead to neurodegeneration and spastic
paraplegia in AP-4 deficient patients.