Study Breakthrough Secures Prize for Best Oral Presentation at UK Platelet Meeting 2015

Dr Mark Thomas, MRC Clinical Training Fellow in the Department of Infection, Immunity & Cardiovascular Disease has recently demonstrated for the first time that anti-clotting medications, which are used for heart attacks, also have a profound impact on human immune responses. This may have an impact on the health of millions of patients who are treated with these medications worldwide.

Electron microscopy to show how infections may change the structure of blood clots by altering the network of fibrin strands that link them together.

The study was presented at the UK Platelet Meeting in Leicester and was awarded the best oral presentation prize. The work was funded by the Medical Research Council and showcases a great team effort by many members of the Department. This was a successful collaboration between Professor Storey, Professor Sabroe and Professor Dockrell of the Department as well as Dr Ramzi Ajjan, University of Leeds.

The manuscript, entitled “Platelet P2Y12 inhibitors reduce systemic inflammation and its prothrombotic effects in an experimental human model” has also just been accepted for publication in Arteriosclerosis, Thrombosis and Vascular Biology (ATVB) journal.

Sheila Francis, Head of Department of the newly formed Department of Infection, Immunity & Cardiovascular Disease commented “Mark’s research is a great example of collaboration across our new Department and has resulted in a publication in a high impact journal”.