Department of Infection, Immunity & Cardiovascular Disease Seminar – Tuesday 24th October 2017

Title: “T-cell immunity in Myocardial Infarction and Healing”.
Speaker: Professor Ioakim Spyridopoulos, Newcastle University.
Venue: Lecture Theatre 3, F Floor Medical School.
Time: 12noon – 1:00pm
Abstract: Over the last decade, the immunological component of cardiovascular disease has garnered increasing interest and study. Coronary artery disease is now known to be largely an inflammatory process and lymphocytes are linked with the entire natural history of the disease, from the fatty streak all the way to plaque rupture, reperfusion injury and ventricular remodelling. We have recently investigated the impact of individual immune cell parameters on long term survival in over 700 octogenarians. Furthermore, we investigated a mechanistic link between Cytomegalovirus (CMV)-seropositivity and the presence of coronary heart disease in the very old. In this study, we have shown that T-cell senescence predicts increased cardiovascular mortality. Expression of the chemokine receptor CX3CR1 is a marker of cytotoxicity in both CD4 and CD8 T-lymphocytes. CMV-specific T-lymphocytes (which make up a significant proportion of total T-lymphocytes) express a cytotoxic phenotype which includes CX3CR1, prompting our hypothesis that T-lymphocytes, expressing CX3CR1, contribute to worse cardiovascular outcomes in CMV seropositive patients. Previous work by our group characterised CX3CR1 dynamics following MI and reperfusion with PCI, suggesting that the mechanism by which T-lymphocytes are disappearing from the blood following reperfusion and also affecting the healing post infarction involves CX3CR1-dependent adhesion and internalisation. In summary, we will try to describe all evidence for the link between an aging immune system and myocardial infarction and healing.