Trabecular or Cortical Bone: How do Osteoblasts Decide when to Consolidate

Friday 15 September 2017
1300 – 1400
Lecture Theatre 3
F Floor Medical School
Associate Professor Natalie Sims
University of Melbourne

Associate Professor Natalie Sims directs the Bone Cell Biology and Disease Unit at St Vincent’s Institute and is an NHMRC Senior Research Fellow and Research Fellow at the University of Melbourne.  She completed her PhD in 1995 at the University of Adelaide, and started her own laboratory in Melbourne in 2001 after postdoctoral studies at the Garven Institute (Sydney) and Yale University.  Her work has defined the roles of Oncostatin M, Cardiotrophin 1, and Leukemia Inhibitory Factor on the development and maintenance of the skeleton, using genetically altered mouse models and in vitro systems.  She has worked closely with Professor T J Martin on developing theories of bone cell communication, particularly with respect to the concept of “coupling”.  Her current work continues to focus on paracrine control of the skeleton, particularly the way parathyroid hormone, IL-6 and STAT1/3 signalling influence bone formationa nd destruction.  She has >100 publications.  Dr Sims is a Senior Editor of the journal Bone and serves on the Editorial Board of the Journal of Biological Chemistry.  Her work has been recognised by the ASBMR Fuller Albright Award (2010) and the International Bone and Mineral Society Herbert A Fleisch Award (2013).

Her talk will focus on the process by which cortical bone forms and how it is regulated by local factors produced by osteocytes, the internal cellular network of the skeleton.

If you would prersonally like to meet the speaker on the day of their seminar contact:
Daniele Swain, Tel 2159667, emal d.m.swain@sheffield.ac.uk
Mellanby Centre Website: http://www.mellanbycentre.org