Lung MRI method detects early lung changes in children with Cystic Fibrosis

Ventilation MRI detects early lung disease in children with Cystic Fibrosis (CF). This type of MRI uses inhaled gases to directly image the airspaces of the lungs. We studied a group of children with CF with very mild lung disease, and found that ventilation MRI was able to detect lung abnormalities which were not detected by other clinical tests (CT, lung clearance index and spirometry). Alongside this group of children with CF we studied healthy children without lung problems, who all had normal ventilation MRI.

Equivalent slices from (left) ventilation MRI, (middle) CT and (right) proton MRI of a patient with CF. Ventilation abnormalities are seen in the ventilation MR image while CT and proton MR images are normal.

This work was recently published in ‘Thorax’.

DOI: and we are excited that the Editors also chose to write about our work: DOI: