REMINDER: Department of Infection, Immunity & Cardiovascular Disease Seminar – Wednesday 10th May 2017

Title:  “How does Endothelial Organelle Size and Golgi Architecture control Haemostasis?”
Speaker:  Professor Dan Cutler, University College London.
Time:  12:30pm – 1:30pm
Venue:  Lecture Theatre 3, F Floor Medical School.
Abstract:  The endothelial secretory organelles called Weibel-Palade bodies contain the haemostatic factor von Willebrand Factor, mutations in which cause the commonest human inherited bleeding disorder, von Willebrands disease.
The structure of VWF controls its functioning in haemostasis, and this structure is modified by a variety of cellular machineries during biosynthesis. We have recently discovered that WPB are made of subunits that are assembled into a range of different sizes of organelles, and that this size controls the functioning of the VWF. How this is done, and how it can be controlled is therefore a novel way to modulate the critical contribution of VWF to haemostasis.

For enquiries, please contact: iicd@sheffield.ac.uk


FUTURE DATES FOR THE DIARY:

Thursday 25th May 2017
Title:  “Endothelial cell fluid shear stress sensing in vascular health and disease”
Speaker:  Professor Martin Schwartz, University of Manchester.
Time:  12:30pm – 1:30pm
Venue:  Lecture Theatre 2, B Floor Medical School.
Abstract:  Atherosclerosis occurs at specific regions of arteries characterized by disturbances in blood flow patterns. Plaques form as a consequence of synergies between flow responses and systemic risk factors such as LDL cholesterol, high blood glucose, smoking, etc. My lab studies fundamental mechanisms of mechanotransduction by flow, how these flow responses are integrated to mediate inflammatory activation of the endothelium, and how these events progress to atherosclerotic plaque. I will present our latest data on the mechanisms of flow signaling, their role in atherosclerosis, and possible new directions for treatment.

Friday 9th June 2017
Title:
“Molecular Medicine meets Haemophilia: Spoiled for choice of future treatments”
Speaker: Professor David Lillicrap, Queen’s University, Kingston, Canada.
Time: 12noon – 1:00pm
Venue: Lecture Theatre 2, B Floor Medical School.
Abstract: After more than four decades of treating haemophilia with “simple” protein replacement therapies, we are witnessing the advent of novel interventions for this inherited disease based on extensive molecular science innovation. As the bar for therapeutic efficacy and safety for haemophilia therapies is already high, there is a requirement for these new treatments to be even better and at least as safe as previous options. This presentation will summarize recent advances in protein engineering and molecular biology resulting in novel treatments that are now reaching the clinic.

Tuesday 20th June 2017
Title:  “Mechanotransduction pathways and the pathogenesis of pulmonary fibrosis”
Speaker:  Professor Gisli Jenkins, University of Nottingham.
Time:  12:30pm – 1:30pm
Venue:  Lecture Theatre 3, F Floor Medical School.
Abstract: To Follow.

Thursday 20th July 2017
Title:
“Dysregulated Endothelial Signals in Pulmonary Arterial Hypertension”
Speaker:  Professor Hyung J. Chun, Yale School of Medicinyomama.
Time: 12:30pm – 1:30pm
Venue: Lecture Theatre 3, F Floor Medical School.
Abstract:  The research program of the Chun Lab at Yale University focuses on dysregulated endothelial signaling that contribute to vascular disease processes such as pulmonary arterial hypertension and atherosclerosis.  Recently identified endothelial signaling pathways that impact the vascular remodeling process of pulmonary arterial hypertension will be discussed.