REMINDER: Department of Infection, Immunity & Cardiovascular Disease Seminar – Wednesday 22nd March 2017

Title:  “Macrophage dynamics in helminth infection: Insights into type 2 immunity and tissue repair”
Speaker:  Professor Judith Allen, University of Manchester
Time:  12:30pm – 1:30pm
Venue:  Lecture Theatre 3, F Floor Medical School.
Abstract:  Macrophages activated by the Th2 cytokines IL-4 and IL-13 are found in high numbers at the site of helminth infection. Macrophage accumulation in this setting can result either from local expansion of the resident population or recruitment of blood monocytes. Proliferative expansion of macrophages in response to IL-4 receptor signalling occurs in a broad range of tissues in both helminth infection and non-infectious settings such as tissue injury. Depending on the infectious agent, host genotype or site of infection/injury, the increase in macrophage number may be due predominantly to proliferation of resident cells or recruitment of monocytes from the blood. Critically, the capacity of macrophages to respond to IL-4 or IL-13 at the site of infection or injury is dictated by local tissue-specific signals. 

For enquiries, please contact: iicd@sheffield.ac.uk


FUTURE DATES FOR THE DIARY:

Tuesday 25th April 2017
Title: 
“The Role of Mitochondrial Dynamics in Human Diseases”
Speaker:  Professor Stephen Archer, Queen’s University Ontario
Time:  12:30pm – 1:30pm
Venue:  Lecture Theatre 3, F Floor Medical School.
Abstract:  Dr Archer is Head of Medicine at Queen’s University, Ontario Canada. His research interests are in oxygen sensing, mitochondrial biology and developing experimental therapeutics for human diseases such as pulmonary arterial hypertension (PAH) and cancer. Dr Archer was a recipient of the prestigious Distinguished Scientist Award from the American Heart Association last year recognising his pioneering work in identify the metabolic mechanisms associated with PAH. Dr Archer’s current research focuses on mitochondrial fission / fusion promoting cell division in PAH and cancer and the role of miRNA.

Wednesday 10th May 2017
Title: 
“How does Endothelial Organelle Size and Golgi Architecture control Haemostasis?”
Speaker:  Professor Dan Cutler, University College London
Time:  12:30pm – 1:30pm
Venue:  Lecture Theatre 3, F Floor Medical School.
Abstract:  The endothelial secretory organelles called Weibel-Palade bodies contain the haemostatic factor von Willebrand Factor, mutations in which cause the commonest human inherited bleeding disorder, von Willebrands disease.The structure of VWF controls its functioning in haemostasis, and this structure is modified by a variety of cellular machineries during biosynthesis. We have recently discovered that WPB are made of subunits that are assembled into a range of different sizes of organelles, and that this size controls the functioning of the VWF. How this is done, and how it can be controlled is therefore a novel way to modulate the critical contribution of VWF to haemostasis.

Thursday 25th May 2017
Title:  “Endothelial cell fluid shear stress sensing in vascular health and disease”
Speaker:  Professor Martin Schwartz, University of Manchester
Time:  12:30pm – 1:30pm
Venue:  Lecture Theatre 3, F Floor Medical School
Abstract:  Atherosclerosis occurs at specific regions of arteries characterized by disturbances in blood flow patterns. Plaques form as a consequence of synergies between flow responses and systemic risk factors such as LDL cholesterol, high blood glucose, smoking, etc. My lab studies fundamental mechanisms of mechanotransduction by flow, how these flow responses are integrated to mediate inflammatory activation of the endothelium, and how these events progress to atherosclerotic plaque. I will present our latest data on the mechanisms of flow signaling, their role in atherosclerosis, and possible new directions for treatment.